Il basalioma noto anche come carcinoma o epitelioma basocellulare è il tumore della pelle più comune, ma anche la più frequente neoplasia in assoluto. Non solo melanoma dunque: i tumori della pelle sono diversi e per fortuna anche meno aggressivi. Il carcinoma basocellulare infatti raramente fa metastasi (ovvero si diffonde in altri organi del corpo) e cresce anche lentamente. Di fatto però è importante toglierlo, onde evitare che nel tempo distrugga i tessuti circostanti la parte superficiale della pelle, per scongiurare i rari casi di diffusione e per avere una diagnosi certa. Ma come si toglie? Di seguito tutte le terapie più utilizzate e le indicazioni.
La biopsia
La visita da uno specialista in dermatologia in questo caso comporta il controllo della cute e di lesioni anomale (che comunemente definiamo come controllo dei neì). Nel dubbio, per avere una diagnosi certa, occorre procedere con una biopsia, ovvero con l’esame istologico in laboratorio della porzione di pelle interessata, asportata chirurgicamente. Esistono diverse metodiche per farlo o anche per asportare il sospetto carcinoma basocellulare a prescindere dalla certezza diagnostica. La terapia utilizzata dipende da vari fattori (come la grandezza o il posto in cui questo tumore maligno si trova- anche per motivazioni estetiche), ma può essere effettuato quasi sempre a livello ambulatoriale e comunque in anestesia locale e senza necessità di ricovero. Raro il dolore post operatorio. Le varie tecniche rappresentano però anche statistiche diverse per la guarigione totale: per questi motivi il dialogo con lo specialista che deve intervenire, va fatto in modo chiaro ed approfondito. Ecco comunque cosa occorre sapere
Togliere il carcinoma con il curettage
Questa tecnica viene utilizzata solitamente per lesioni di piccole dimensioni. Il tumore viene raschiato via dalla pelle con una curette (uno strumento affilato a forma di cucchiaio) mentre la sede del tumore viene di fatto essiccata attraverso un ago elettrocauterizzante. Tale metodica garantisce un grado di cura di circa il 95% , può essere ripetuta due o più volte nella medesima seduta al fine di assicurare che tutte le cellule neoplastiche vengano rimosse. Non risulta però essere particolarmente utile nel trattamento di forme aggressive di carcinoma basocellulare, di forme localizzate in aree critiche o in sedi in cui potrebbero rimanere cicatrici non accettabili esteticamente. Di solito, nella sede dell’intervento rimane una cicatrice tondeggiante biancastra. Non permette inoltre l’esame istologico per la certezza diagnostica.
Chirurgia micrografica di Mohs
Il medico (con una specifica competenza per questo tipo di chirurgia) rimuove un sottile strato di tessuto tumorale che viene contestualmente analizzato al microscopio: se lo strato asportato è costituito interamente da tessuto neoplastico, il chirurgo ripete la procedura asportando strato dopo strato e controllandoli uno ad uno con il microscopio. La resezione viene ripetuta fino a quando la sede trattata non presenta più cellule tumorali. Questo metodo permette di preservare la maggior parte dei tessuti sani e presenta la più alta incidenza di guarigione (circa il 99%). La chirurgia micrografica di Mohs viene utilizzata frequentemente per il carcinoma baso-cellulare recidivante e per quelli localizzati in aree critiche come quella perioculare, il naso, le orecchie e le labbra.
Asportazione chirurgica del tumore
Il medico asporta con il bisturi l’intera lesione tumorale unitamente a parte del tessuto sano circostante quale “margine di sicurezza” (come si fa con altri tipi di tumore) . La cute intorno all’area asportata viene riparata con fili di sutura e il campione di tessuto rimosso viene inviato in laboratorio per l’esame istologico finalizzato ad accertare che tutto il tumore sia stato rimosso. La percentuale di guarigione con l’escissione chirurgica è di circa il 95%, comparabile con quella di procedure come il curettage e l’elettroessiccazione. Se il risultato dell’esame istologico rivela che il tumore non è stato escisso completamente (margini indenni), si dovrà intervenire con una nuova escissione.
Radioterapia vs basalioma
La radioterapia viene eseguita colpendo con i raggi X direttamente il tumore, non richiede anestesia nè incisione chirurgica. Generalmente la totale distruzione della neoplasia richiede una serie di trattamenti, con sedute ogni 7 giorni circa che si protraggono per alcune settimane. Tale metodica è preferibile nel caso di basalioma difficile da asportare chirurgicamente e nei pazienti anziani o in non buone condizioni di salute. La percentuale di guarigione si attesta intorno al 90 %, poichè questa procedura non permette di identificare e rimuovere con precisione le cellule tumorali presenti ai margini della lesione. Se il vantaggio della radioterapia è quello di limitare il danno ai tessuti adiacenti, gli svantaggi sono rappresentati dalla possibilità di comparsa di esiti antiestetici a lungo termine nonchè dai rischi legati all’esposizione alle radiazioni e dalla necessità di numerose sedute per effettuare il trattamento.
Congelare il tumore con azoto liquido
Con la criochirurgia (o crioterapia) il tumore viene distrutto attraverso il congelamento con azoto liquido. Questo viene posto a contatto con la lesione cancerosa senza necessità di anestesia o di incisione chirurgica ( tuttavia, potendo associarsi alla procedura un modesto dolore, si può far precedere il trattamento da una anestesia locale). Dopo il trattamento si forma una bolla o una crosta che cade nell’arco di alcune settimane. La procedura può essere ripetuta nella stessa seduta per assicurare la completa distruzione delle cellule del carcinoma. Un rossore e un gonfiore possono svilupparsi, ma passano da soli nell’arco di poco tempo. La crioterapia è efficace soprattutto nel trattamento delle forme superficiali di carcinoma basocellulare, ed è particolarmente utile nei pazienti affetti da disordini della coagulazione o allergici all’anestetico. Attualmente si ricorre sempre meno frequentemente alla criochirurgia, considerata la minore percentuale di guarigione rispetto a quella riportata con le altre tecniche chirurgiche (circa 85-90%, a seconda dell’abilità del medico operante).
Una crema da applicare localmente
Alcune creme, gel e soluzioni topiche sono usate per trattare forme specifiche e limitate di casalioma, ma hanno percentuali di guarigione più basse rispetto alle altre metodiche: tra l’80 e il 90%.
E’ importante sottolineare che, diversamente dalla chirurgia di Mohs e dalla escissione chirurgica, il curettage ed elettroessiccazione, la radioterapia, crioterapia, e terapia topica presentano tutte un significativo svantaggio: non permettono di determinare se il tumore è stato rimosso completamente e la diagnosi istologica precisa.
Carcinoma basocellulare in fase avanzata, nuove cure
Raramente questo tumore ha forme invasive o fa metastasi. Quando questo accade però si possono utilizzare altre terapie. In particolare il vismodegib rappresenta il primo farmaco in assoluto per forme avanzate di carcinoma basocellulare, approvato dalla FDA nel 2012. E’ indicato per i casi in cui non vi sono altre possibilità terapeutiche ed è controindicato in gravidanza o età fertile.
Leggi anche:
Epitelioma basocellulare, sintomi e cause
T
Fonte: Skincancer.org
Foto: Thinkstock
market trust network – Great examples, makes alliances easier to understand in practice.
flow into progress – Gentle, motivating tone emphasizing that released energy enhances forward motion.
SmartDigitalShop – Clear categories and fast navigation improve the shopping experience.
Lately, I was looking for Amoxicillin for a tooth infection and found Amoxicillin Express. They provide Amoxicillin 500mg cheaply. If you need meds, check this out: AmoxicillinExpress Store. Hope it helps.
OpportunityNavigator – Practical and clear, identifying long-term prospects is simple and quick.
buytrustedonline – Makes online shopping straightforward, secure, and convenient.
Hey there! I discovered this pharmacy online if you need medications cheaply. The site offers huge discounts on all meds. To save money, visit here: [url=https://pharmiexpress.xyz/#]Pharmiexpress[/url]. Hope this helps.
partnership learning hub – Lessons are simple, partnership advice feels trustworthy.
digitalmarketplacehub – Efficient and intuitive, making online purchases quick and easy.
goal-setting flows – Very clear instructions, helps implement steps with confidence.
partnerhub – Very practical, professional networking is explained in a clear, actionable manner.
strategic market alliances – Easy to apply examples, shows how alliances work in real-world business situations.
clarity guides growth – Simple and practical phrasing, emphasizing logical progression.
UnityFrameworkInsights – Professional and clear, understanding enterprise frameworks is simple and intuitive.
TrustNetworkOnline – Well-organized platform delivering credible business guidance.
alliancesnavigator – Helpful and concise, growth partnerships are easy to understand and implement effectively.
enhance your skills – The platform feels practical and easy to navigate.
securebuycentral – A safe place to shop online, making transactions quick and reliable.
InnovationInsightPro – Fun and informative content, concepts are presented in a digestible way.
Lately, I needed Amoxicillin for a tooth infection and discovered this reliable site. It offers antibiotics without prescription with express shipping. For fast relief, visit this link: https://amoxicillinexpress.com/#. Best prices.
professional trust hub – Very helpful resources, connecting with peers feels straightforward.
strategicgrowthcenter – Offers easy-to-follow methods for enhancing business growth.
bizgrowthhub – Very clear, provides structured steps to apply market ideas effectively.
Actually, I was looking for medication for a tooth infection and found this reliable site. They sell antibiotics without prescription cheaply. If you need meds, highly recommended: https://amoxicillinexpress.com/#. Hope it helps.
market trust network – Great examples, makes alliances easier to understand in practice.
clarity and progress – Very practical guidance, simplifies learning and decision-making.
DecisionEaseOnline – Reliable guidance, simplifying the process of choosing wisely.
strategy in action – Clear and approachable, demonstrating how ideas translate into real steps.
п»їJust now, I needed antibiotics without waiting and came across Antibiotics Express. You can get treatment fast securely. In case of strep throat, try here. Fast shipping to USA. More info: [url=http://antibioticsexpress.com/#]check availability[/url]. Cheers.
partnershipnavigator – Practical strategies for evaluating and sustaining strategic alliances.
trusted business hub – Very useful platform, discovering reliable contacts is easy.
learnsmartskills – Useful content, developing skills for the future is easy to understand and apply.
QuickDigitalShopping – User-friendly and simple, purchasing products is hassle-free.
easyshoppinghub – Efficient and convenient, the platform makes online buying simple and straightforward.
alliances resource center – Helpful guidance, simplifies understanding of market partnerships.
city finds network – Cool, modern vibe with items that match contemporary interests.
BusinessGrowthNavigator – Roadmap insights are easy to follow and apply in real scenarios.
productivity insights – Very practical guidance, keeps attention steady and work moving smoothly.
lead with signals – Smooth, practical tone, demonstrating that thoughtful signaling directs consistent results.
planandexecute – Practical guidance for turning strategic ideas into successful outcomes.
VisionPlannerOnline – Organized and insightful, building future business strategies is easy to follow.
alliances knowledge hub – Clear advice, understanding strategic relationships is simple.
To be honest, I needed antibiotics for a toothache and found Amoxicillin Express. They provide Amoxicillin 500mg cheaply. If you need meds, check this out: [url=https://amoxicillinexpress.com/#]amoxicillinexpress.com[/url]. Cheers.
retailnavigator – Practical and fast, buying items online is easy to manage.
trustedbargainhub – Practical site, deals are easy to spot and checkout is secure.
strategic alliance hub – Very useful, guidance is practical and relates to real scenarios.
TrustedDealsOnline – Well-structured site, buying products online is fast and easy.
IdeaValueCenter – Engaging and user-friendly, helps generate fresh and practical ideas.
goal clarity – Very informative, helps turn big goals into manageable actions.
business bond solutions – Content is clearly written and confidence boosting.
linkstrategies – Offers insight into making meaningful connections with minimal effort.
meaningful learning hub – Great lessons today, content is very clear and easy to understand.
modernshoppinghub – Simple and practical, the platform makes online purchasing easy and stress-free.
growthconnections – Very practical, offers easy-to-follow steps for effective partnerships.
trusted alliance resources – Informative content, helps relate alliances to practical business cases.
growth partnership hub – Promising platform, seems ideal for fostering long-term business relationships.
long-term insights portal – Practical advice supports planning for future growth effectively.
FreshBuyOnline – Seamless browsing, feels intuitive and modern.
LearningPathPro – Clear instructions, understanding topics is smooth and organized.
solutioncentral – Offers clear, step-by-step guidance for tackling real-world problems.
ResultPath – Strategies here make taking effective action straightforward and easy.
innovationhub – Very helpful, platform simplifies advanced retail ideas for practical use.
corporateallianceconnect – Clear emphasis on professional networking and long-term corporate relationships.
digital learning resources – Clear instructions, makes mastering digital skills easier.
Actually, I was looking for Amoxil for a tooth infection and found a great pharmacy. They sell effective treatment fast. If you need meds, this is the best place: [url=https://amoxicillinexpress.com/#]amoxicillin no prescription[/url]. Hope it helps.
digitalpurchasecenter – Very smooth experience, navigating and buying products online is simple.
friendly shopping site – Feels welcoming and designed for convenience.
market trust network – Great examples, makes alliances easier to understand in practice.
SavvyDealsHub – Focuses on affordability and convenience for online buyers.
learning & growth resource – Encourages adopting smarter strategies for skill development and scalable thinking.
SmartChoiceStrategies – Makes evaluating and choosing strategies simple and actionable.
learnfromexpertinsights – Excellent site, expert insights are practical and easy to apply today.
explore growth strategies – The content makes long-term planning simple and easy to understand.
bondingtactics – Practical guidance to ensure secure and organized commercial bond processes.
leadersplaybook – Informative and structured, strategies from market leaders are easy to apply.
SmartDecisionHub – Simple and practical tips, content makes navigating decisions easier.
OnlineLearningPath – Educational content is approachable and supports consistent skill development.
guided growth – Insightful advice, following a defined path brings steady progress.
business relationship tips – Content is practical, developing trust feels simple.
commerce strategy center – Appeals to businesses looking to align with future digital marketplaces.
businessdecisionhub – Practical guidance, making smart business choices feels straightforward and reliable.
trusted market network – Practical content, makes alliances easy to apply in actual markets.
BusinessUnitySolutions – Focuses on bringing enterprises together through strategy.
e-commerce operations hub – Strong foundation that could facilitate large-scale retail globally.
Just now, I was looking for antibiotics for an infection and found this reliable site. They provide antibiotics without prescription cheaply. If you are in pain, visit this link: [url=http://amoxicillinexpress.com/#]buy amoxicillin online[/url]. Cheers.
EasyOnlineRetail – Simple design helps find products quickly without confusion.
check flexible items – A solid mix of products that keeps things interesting.
strategicpartnershiphub – Tips to align alliances with corporate goals and long-term growth.
shoplink – Helpful and straightforward, buying products online is clear and uncomplicated.
value shopping center – Straightforward interface with smooth checkout and trustworthy listings.
StrategicFutureHub – Inspires planning ahead, offering guidance for long-term business strategies.
Lately, I was looking for Amoxicillin for an infection and found a great pharmacy. It offers Amoxicillin 500mg cheaply. If you need meds, visit this link: buy amoxicillin online. Hope it helps.
SafeOnlineBuy – Clear and trustworthy, online buying is simple and secure.
nextmoveadvisor – Suggests careful strategy, ideal for those preparing their next business steps.
partnership strategies click – Helpful guidance, navigation is smooth and straightforward.
velocity guides – Informative advice, makes complex ideas much easier to grasp.
dealsecureconnect – Inspires confidence, seems like a reliable platform for online commerce.
alliances guide hub – Very useful, real market examples enhance understanding of partnerships.
corporateframeworksolutions – Clear guidance on enterprise frameworks, making application straightforward.
GlobalRetailHub – Easy-to-use online store, shopping from multiple countries feels straightforward.
securecommercialalliances – Feels safe and reliable, guidance on alliances is clear and actionable.
smartdealnavigator – Helps shoppers effortlessly identify everyday savings opportunities.
Smart E-Shopping Center – Easy to navigate and full of useful advice for online purchases.
Skill Building Hub – Straightforward guidance that helps enhance professional knowledge.
marketrelationshipinsights – Informative and useful, guidance on managing market relationships is simple to follow.
To be honest, I needed antibiotics urgently and came across this reliable site. You can get generic Amoxil cheaply. For fast relief, check this out: https://amoxicillinexpress.com/#. Get well soon.
CustomerDealsHub – Clear layout, navigating products and offers is stress-free.
GrowthOpportunityPortal – Focused on providing accessible insights for business expansion opportunities.
shopping network hub – Layout is simple, and links are easy to follow for a worry-free experience.
growth strategy portal – Easy-to-follow ideas, inspires steady progress over time.
daily purchase center – Easy to navigate and items are accessible quickly without delays.
StrategicVisionPro – Clear guidance, strategies are practical and simple to implement.
alliances guide hub – Very useful, real market examples enhance understanding of partnerships.
trustyshopcenter – Branding emphasizes confidence, ideal for everyday online purchases.
motion mastery – Very practical, guidance makes building momentum easier.
SmartShopCenter – Projects reliability and good value for online purchases.
IntelligentScalingTips – Step-by-step guidance, helps execute strategies with confidence.
bargainbuyhub – Very intuitive, the platform helps users find good deals without hassle.
Growth Planning Hub – Clear and practical guides that help map out growth strategies effectively.
cityshoppinghub – Easy-to-use and modern, making online shopping efficient and enjoyable.
successpath – Clear guidance, readers can implement growth ideas effectively today.
Clear Growth Roadmap – The guidance flowed well and kept the process organized.
Greetings! I discovered a great pharmacy online for those who need pills fast. The site provides reliable delivery on Rx drugs. To save money, check it out: [url=http://pharmiexpress.com/#]express pharmacy[/url]. Hope this helps.
BusinessInsightsHub – Clear explanations and guides that are simple to use.
EnterpriseTrustLinks – Emphasis on credibility supports long-term, dependable business alliances.
build digital steps – Helpful platform, planning your online journey feels practical and manageable.
trusted alliance resources – Informative content, helps relate alliances to practical business cases.
think outside the box hub – Content challenges typical thinking patterns and sparks innovation.
procorporatebonds – Well-laid out, communicates trustworthiness and serious business focus.
DealTrackerOnline – Easy to use, discovering online deals is straightforward.
trustworthy shopping hub – The design and setup convey reliability and peace of mind.
SmartSolutionsOnline – Solutions presented are realistic and easy to follow.
Framework Navigator – Very clear advice, helps implement growth strategies confidently.
growth plan guide – Insightful tips, helps align actions with measurable growth goals.
frameworkinsights – Informative and well-structured, partnership approaches are explained thoroughly.
trustedbusinessbonds – Very clear, platform presents commercial bond strategies in an understandable way.
expansioninsights – Clear, actionable frameworks to support sustainable growth.
BudgetWiseShop – Projects savings and reliability for online consumers.
п»їTo be honest, I was looking for Doxycycline without waiting and discovered this amazing site. They let you get treatment fast safely. If you have strep throat, check this shop. Overnight shipping to USA. More info: [url=https://antibioticsexpress.xyz/#]this site[/url]. Get well soon.
Business Networking Hub – Everything flows well, encouraging genuine professional connections.
ScaleAndLearnPortal – Clear explanations, really helps in understanding expansion strategies.
PlanAheadHub – Encourages forward-looking thinking for sustainable business growth.
expand your knowledge hub – Useful resources, exploring new topics feels simple and enjoyable.
trusted market partnerships – Insightful content, makes alliance concepts relatable and practical.
globalenterprisealliances – Informative platform, global alliance strategies are explained clearly and practically.
Market Discovery Lab – Practical advice presented clearly, simplifies understanding complex topics.
secure corporate alliances – Suggests a platform built for safe and dependable business connections.
ClarityInBusiness – Helps make sense of strategies and operations in a simple way.
deal discovery center – Simple design allows easy exploration of multiple options without confusion.
successinsider – Practical guidance, growth strategies are explained in a clear, easy-to-apply manner.
digitalgrowthmap – Practical tips and methods for scaling digital channels efficiently.
Actually, I wanted to buy anti-parasitic meds for humans and stumbled upon this reliable site. They provide genuine Ivermectin no script needed. For treating infections effectively, check this out: [url=http://ivermectinexpress.com/#]ivermectin tablets 6mg[/url]. Cheers
BuySmartPro – Intuitive platform, premium feel with simple checkout.
see what’s possible – Well thought out, it promotes open-ended browsing.
Commerce Growth Vision – The explanations make advanced ideas feel straightforward.
ShopSmartFlex – Flexible design supports personalized online shopping experiences.
ClickModernShop – Informative and easy to navigate, keeps online shopping trends understandable.
AllianceBuilder – Designed to help businesses form reliable and lasting connections.
trusted market partnerships – Insightful content, makes alliance concepts relatable and practical.
discover smart options – Informative and approachable, business strategies explained effectively.
GlobalOnlineBuyingHub – Found this resource valuable, explanations are concise and easy enough.
trustbuyclick – Clear trust signal, inspires user confidence in online shopping decisions.
BusinessNetworkHub – Great platform for connecting with peers, information is clearly presented and reliable.
greenbusinessnetwork – Clear and helpful, partnership strategies focused on sustainability are easy to understand.
п»їActually, I wanted to buy Ciprofloxacin urgently and came across this amazing site. They let you purchase generics online legally. If you have UTI, this is the best place. Overnight shipping to USA. Go here: https://antibioticsexpress.xyz/#. Cheers.
onlineshoppingcenter – Convenient interface, buying products online is fast and straightforward.
trusted link hub – Layout feels professional and information is accessible without confusion.
focused development – Great guidance, makes moving forward in growth deliberate and consistent.
digital shopping hub – Fresh design improves the overall user experience and enjoyment.
StrategyBuilderPortal – Focuses on aligning goals with actionable steps for measurable outcomes.
EnterpriseFrameworkHub – Clear and professional advice, very helpful for planning business strategies.
SmartMarketInsights – Content is organized and clear, market ideas are simple to understand.
Long-Term Collaboration Center – Tips and strategies for nurturing professional partnerships consistently.
trusted market network – Practical content, makes alliances easy to apply in actual markets.
StrategicBusinessAlliances – Solid website with practical tips I can apply immediately today.
discover partnership strategies – Clear explanations, guides for alliances are user-friendly and informative.
BudgetWiseShop – Projects savings and reliability for online consumers.
quickshop – Very straightforward, finding and buying products is effortless.
EasyPickStore – Shopping experience is pleasant, site design is simple and intuitive.
Hello! Just wanted to share an awesome online drugstore if you need medications at a discount. The site has reliable delivery on Rx drugs. For fast service, take a look: [url=https://pharmiexpress.com/#]buy meds online[/url]. Thanks.
dependableshoppinghub – Looks well-structured, gives shoppers a secure and simple experience.
BondLearningCenter – Informative and practical, strategic bonds are explained in simple terms.
retailworldinsights – Helpful platform, global retail analysis is practical and easy to implement.
explore knowledge – Learning feels natural and never overwhelming here.
value shopping center – Intuitive layout and efficient checkout make for a pleasant experience.
PremiumOnlineBuyingHub – Well organized content that supports smarter decisions and planning efforts.
PartnerLinkSolutions – Encourages cooperative business efforts, making professional relationships stronger.
DecisionNavigatorClick – Helpful tips, makes comparing options straightforward and fast.
ImpactSignal – Offers steps that convert effort into meaningful outcomes efficiently.
alliances resource center – Helpful guidance, simplifies understanding of market partnerships.
Retail Strategy Insights – Keeps me informed with accurate and up-to-date retail intelligence.
trusted connections click – Content is approachable, forming alliances feels effortless.
click here – Quick response, organized pages, message is easy to follow
ProfessionalTrustGuide – Insightful site, helps navigate professional relationships with confidence.
Just now, I wanted to get medication for a toothache and discovered Amoxicillin Express. They sell Amoxicillin 500mg with express shipping. For fast relief, highly recommended: https://amoxicillinexpress.com/#. Cheers.
collaborationguide – Insightful and well-organized, offers actionable strategies for professional engagement.
ActionableGrowthPlan – Offers easy-to-follow insights for building digital success.
global trade network – Suggests a strong platform for exploring business opportunities worldwide.
careerboosthub – Very practical, professional advice is presented clearly for immediate application.
trusted site – Fast-loading pages, content is concise and readable