Un semplice prelievo del sangue per monitorare la stabilità genetica di soggetti sani e eventualmente scoprire anomalie che potrebbero essere collegate alla presenza di tumori.
Tutto questo è HELIXAFE, il programma sviluppato da Bioscience Genomics, spin off dell’Università di Tor Vergata che permette di valutare il profilo individuale di stabilità genetica, che si aggiorna periodicamente (ogni anno) mediante la ripetizione del test della lettura delle mutazioni. Quanto più il monitoraggio si estende nel tempo, tanto più diventa accurato il risultato. Il dottor Andrea Mancuso, Ricercatore Clinico e Traslazionale del Reparto di Oncologia Medica dell’Ospedale San Camillo Forlanini di Roma, sottolinea l’importanza di questo progetto per la pronta individuazioni di rischi correlati a tumori:
Questo progetto offrirà all’oncologo medico una potenzialità diagnostica e terapeutica in tutte le fasi di gestione del paziente dal follow-up al monitoraggio dell’efficacia della terapia oncologica e alle scelte terapeutiche successive. Provvederà all’interno di trial clinici di impattare sulla sopravvivenza globale del paziente riducendo le terapie inefficaci e migliorare o addirittura eliminare effetti iatrogeni
Piuttosto che cercare cellule o DNA tumorali nel sangue, che sono presenti solo quando il tumore è già sviluppato e a volte già in stato avanzato, il programma Helixafe esegue il monitoraggio periodico delle mutazioni somatiche per intercettare l’eventuale instabilità genetica che anticipa lo sviluppo della patologia.
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