Tumori, il farmaco jolly che contrasta 29 tipi di neoplasie 

di

 

Un nuovo, nuovissimo farmaco jolly in grado di poter aggredire e spegnere ben 29 tipi di tumori diversi: si chiama larotrectinib, ed è il primo farmaco primo nella classe degli inibitori orali di TRK che è stato presentato nel corso del Congresso europeo di oncologia Esmo che si sta tenendo in questi giorni nella città di Barcellona. 

tumore farmaco

Un farmaco innovativo che agisce non direttamente sull’organo dove il cancro ha avuto origine, ma sulla stessa alterazione genica, la “Ntrk” che si riscontra essere comune a cellule cancerose di diversi tipi di cancro. 

Senza dimenticare che il larotrectinib non avrà gravi effetti collaterali sul paziente. 

Farmaco jolly contro i turmori, che cos’è il Larotrectinib

Si chiama larotrectinib ed è il primo nella classe degli inibitori orali di TRK che solo pochi giorni fa ha incassato il via libera alla commercializzazione nell’Unione europea dopo avere ottenuto il permesso alla commercializzazione negli Stati Uniti, in Brasile e in Canada. 

Gli stupefacenti risultati della molecola larotrectinib sono stati presentati al Congresso europeo di oncologia Esmo. I dati confermano che l’assunzione del farmaco presenta una riduzione del 30% della massa tumorale nel 79% dei pazienti valutati e nel 75% di quelli con metastasi cerebrali con sopravvivenza media inferiore ai tre anni. Dati eccezionali insomma secondo la comunità scientifica. 

Come agisce il Larotrectinib

Il Larotrectinib viene comunemente definito un farmaco “agnostico” poiché non agisce direttamente su un solo organo in particolare, ma indipendentemente dalla localizzazione del tumore. 

Un farmaco che crea un precedente perché la molecola riesce ad agire sui tumori solidi anche in stadio molto avanzato o metastatico sia nei pazienti adulti sia nei pazienti pediatrici. 

Il Larotrectinib inoltre agisce non direttamente sull’organo, ma sulla alterazione genica di Ntrk responsabile del tumore, alterazione rara, ma che solo in Italia arriva a colpire oltre 4mila pazienti l’anno. 

Il nuovo farmaco messo a punto inoltre viene somministrato per bocca con effetti collaterali molto lievi e senza devastanti effetti collaterali. 

Le fusioni geniche di Ntrk, che cosa sono

Le fusioni geniche di Ntrk sono alterazioni presenti in tante diverse neoplasie, fino a 29, che scatenano un’attivazione incontrollata del recettore TRK (Tropomyosin Receptor Kinase) contribuendo alla crescita del tumore. 

Il larotrectinib (LOXO-101) riesce invece ad agire sulle proteine di fusione della chinasi del recettore della tropomiosina (TRK).

 

TUMORE ALLA OVAIE, COME FUNZIONA LA PREVENZIONE

TUMORE AL SENO, PREVENZIONE CON DIETA MEDITERRANEA?

TUMORE AI TESTICOLI, PIU’ DIFFUSO AL NORD

 

 

46 commenti su “Tumori, il farmaco jolly che contrasta 29 tipi di neoplasie ”

  1. I haven?t checked in here for a while as I thought it was getting boring, but the last few posts are good quality so I guess I will add you back to my daily bloglist. You deserve it my friend 🙂

  2. UpvoteRocket delivers anonymous automated votes to 25+ game server toplists XtremeTop100, GTop100, TopG, MMtop200, RagnaTOP, MuTop100 and more. Undetectable, no bans, no risk. Pay only per successful vote delivered. Launch a campaign in seconds and rank higher today.

  3. I used to be very pleased to find this web-site.I wished to thanks for your time for this excellent learn!! I undoubtedly having fun with each little little bit of it and I’ve you bookmarked to check out new stuff you weblog post.

  5. I have discovered some important matters through your website post. One other point I would like to say is that there are numerous games that you can buy which are designed mainly for toddler age young children. They contain pattern identification, colors, creatures, and shapes. These usually focus on familiarization rather than memorization. This helps to keep little kids occupied without sensing like they are learning. Thanks

  6. Hey there, You’ve done a fantastic job. I?ll definitely digg it and personally recommend to my friends. I am confident they will be benefited from this web site.

  7. you are actually a excellent webmaster. The site loading speed is amazing. It kind of feels that you are doing any distinctive trick. Furthermore, The contents are masterpiece. you have done a great task in this subject!

  8. I’ve learned new things by means of your website. One other thing I’d like to say is that often newer laptop os’s are inclined to allow much more memory to be utilized, but they as well demand more storage simply to run. If your computer is unable to handle a lot more memory as well as the newest computer software requires that memory space increase, it might be the time to shop for a new Computer. Thanks

  9. Hey There. I found your blog using msn. This is an extremely well written article. I?ll make sure to bookmark it and come back to read more of your useful info. Thanks for the post. I?ll definitely comeback.

  10. http://www.factorytinsigns.com is 100 Trusted Global Metal Vintage Tin Signs Online Shop. We have been selling art and décor online worldwide since 2008. Started in Sydney, Australia. 2000+ Tin Beer Signs, Outdoor Metal Wall Art, Business Tin Signs, Vintage Metal Signs to choose from. 100 Premium Quality Artwork. Up-to 40 OFF Sale Store-wide. Fast Shipping USA, Canada, UK, Australia, New Zealand, Europe.

  12. I learned more something totally new on this losing weight issue. A single issue is a good nutrition is tremendously vital while dieting. A massive reduction in junk food, sugary meals, fried foods, sugary foods, pork, and white colored flour products could possibly be necessary. Having wastes organisms, and toxins may prevent aims for shedding fat. While specific drugs in the short term solve the situation, the terrible side effects are certainly not worth it, plus they never offer you more than a short-lived solution. It can be a known incontrovertible fact that 95 of diet plans fail. Many thanks sharing your notions on this site.

  14. Undeniably believe that which you stated. Your favorite reason seemed to be on the net the simplest thing to be aware of. I say to you, I certainly get annoyed while people think about worries that they just don’t know about. You managed to hit the nail upon the top and also defined out the whole thing without having side effect , people can take a signal. Will probably be back to get more. Thanks

  15. http://www.factorytapestry.com is a Trusted Online Wall Hanging Tapestry Store. We are selling online art and decor since 2008, our digital business journey started in Australia. We sell 100 made-to-order quality printed soft fabric tapestry which are just too perfect for decor and gifting. We offer Up-to 50 percent OFF Storewide Sale across all the Wall Hanging Tapestries. We provide Fast Shipping USA, CAN, UK, EUR, AUS, NZ, ASIA and Worldwide Delivery across 100+ countries.

  16. I?ll immediately grab your rss feed as I can’t find your e-mail subscription link or e-newsletter service. Do you have any? Please let me know so that I could subscribe. Thanks.

  17. Thanks for your post. I also believe laptop computers have become more and more popular nowadays, and now in many cases are the only form of computer utilised in a household. This is due to the fact that at the same time that they are becoming more and more economical, their computing power keeps growing to the point where these are as highly effective as pc’s from just a few years ago.

  18. Greetings from Los angeles! I’m bored to tears at work so I decided to check out your blog on my iphone during lunch break. I love the info you provide here and can’t wait to take a look when I get home. I’m shocked at how fast your blog loaded on my mobile .. I’m not even using WIFI, just 3G .. Anyhow, very good site!

  19. I also believe that mesothelioma cancer is a extraordinary form of cancer that is often found in those people previously familiar with asbestos. Cancerous cells form from the mesothelium, which is a protecting lining which covers many of the body’s areas. These cells generally form within the lining with the lungs, stomach, or the sac which encircles the heart. Thanks for discussing your ideas.

  20. Great ? I should definitely pronounce, impressed with your website. I had no trouble navigating through all the tabs and related information ended up being truly easy to do to access. I recently found what I hoped for before you know it at all. Reasonably unusual. Is likely to appreciate it for those who add forums or something, website theme . a tones way for your client to communicate. Excellent task..

  21. Riding a quad bike in Dubai sounds like an adventure worth trying. It gives visitors a chance to experience the desert in a more exciting way. I think it would be one of the best parts of a Dubai trip.

  22. Hey I am so happy I found your website, I really found you by error, while I was looking on Google for something else, Anyhow I am here now and would just like to say thanks a lot for a remarkable post and a all round exciting blog (I also love the theme/design), I don’t have time to read it all at the moment but I have book-marked it and also added your RSS feeds, so when I have time I will be back to read a lot more, Please do keep up the fantastic job.

  23. Thanks for this wonderful article. Also a thing is that almost all digital cameras are available equipped with any zoom lens that enables more or less of a scene to be included by means of ‘zooming’ in and out. These kind of changes in {focus|focusing|concentration|target|the a**** length are usually reflected from the viewfinder and on significant display screen at the back of your camera.

  25. I have been absent for some time, but now I remember why I used to love this site. Thanks , I will try and check back more frequently. How frequently you update your web site?

  26. I have learned some new items from your web site about computers. Another thing I’ve always considered is that laptop computers have become an item that each house must have for many reasons. They supply you with convenient ways to organize homes, pay bills, go shopping, study, pay attention to music as well as watch tv series. An innovative strategy to complete most of these tasks is a laptop. These pc’s are portable ones, small, highly effective and transportable.

  27. One thing I’d really like to reply to is that weight loss program fast can be performed by the correct diet and exercise. Someone’s size not simply affects the look, but also the general quality of life. Self-esteem, melancholy, health risks, in addition to physical ability are afflicted in fat gain. It is possible to make everything right and at the same time having a gain. If this happens, a problem may be the root cause. While an excessive amount food but not enough exercise are usually the culprit, common medical ailments and popular prescriptions could greatly enhance size. Kudos for your post right here.

  28. One more important area is that if you are an elderly person, travel insurance for pensioners is something you need to really consider. The more aged you are, the greater at risk you might be for making something undesirable happen to you while abroad. If you are not necessarily covered by a number of comprehensive insurance policy, you could have some serious troubles. Thanks for revealing your advice on this website.

  29. A person essentially help to make seriously posts I would state. This is the very first time I frequented your web page and thus far? I surprised with the research you made to create this particular publish incredible. Great job!

  30. Hi, Neat post. There is a problem along with your site in internet explorer, may check this? IE still is the marketplace leader and a good component to other people will pass over your wonderful writing due to this problem.

  31. I do agree with all of the ideas you’ve presented in your post. They’re really convincing and will definitely work. Still, the posts are too short for novices. Could you please extend them a little from next time? Thanks for the post.

  37. Wonderful blog! I found it while searching on Yahoo News. Do you have any suggestions on how to get listed in Yahoo News? I’ve been trying for a while but I never seem to get there! Many thanks

  43. Oh my goodness! an amazing article dude. Thanks Nonetheless I’m experiencing difficulty with ur rss . Don?t know why Unable to subscribe to it. Is there anybody getting equivalent rss downside? Anyone who is aware of kindly respond. Thnkx

  44. Howdy just wanted to give you a quick heads up. The words in your post seem to be running off the screen in Internet explorer. I’m not sure if this is a formatting issue or something to do with web browser compatibility but I thought I’d post to let you know. The design look great though! Hope you get the issue resolved soon. Thanks

  45. I?ve been exploring for a little for any high quality articles or blog posts on this kind of area . Exploring in Yahoo I eventually stumbled upon this site. Studying this information So i am glad to express that I’ve an incredibly just right uncanny feeling I came upon just what I needed. I such a lot definitely will make sure to do not disregard this website and give it a look regularly.

  46. TopVote.bot helps game server owners automate promotion and buy votes for their preferred toplists. Can’t find the website you need? Request any toplist, and we will build support for it. Launch campaigns in 2 minutes, pay only for successful votes, and keep your unused tokens forever.

Lascia un commento

Powered by  GDPR Cookie Compliance
Panoramica privacy

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.